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Although this does not preclude for a role of NO in TB in humans, as attested by in vitro and ex vivo experiments [28], [29], this result is a clear discrepancy with that observed in mouse phagocytes, especially in Mφs, in which mycobacterial infection induces NOS2 transcription and NO production [7].
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Szmigielski and coworkers have reported that mouse phagocytes are less susceptible to lysis compared to human phagocytes and show an approximate ten fold difference in membrane permeability following purified PVL toxin challenge as measured by 51-Cr release assay [34].
Voltage-gated proton current (IHv) has been characterized in several cell types, but the majority of the data was collected in phagocytes, especially in human granulocytes.
The bacterium invades and replicates in phagocytes, especially in polymorphonuclear granulocytes.
It is poorly expressed in resting mouse phagocytes [ 18] and strongly induced upon stimulation with bacterial components or infection in vitro and in vivo [ 18, 19].
Interestingly, some researchers have shown that in the absence of circulating antibody, Fc receptor mediated internalization of L. mexicana in mouse phagocytes is compromised, leading to increased host protection.
These numbers differ for mouse and especially for chicken samples.
Given the pivotal role of phagocytes and especially alveolar macrophages in pulmonary immunity, we introduce a new, cell-based treatment strategy to target bacterial airway infections.
Considering phagocytes, and especially alveolar macrophages as critical regulators in the maintenance of lung homeostasis and pulmonary immunity7,8,9, here we evaluate the therapeutic potential of iPSC-derived macrophages (iPSC-Mac) for the treatment of pulmonary infections caused by P. aeruginosa.
Using the mouse, especially for those with tremors and arthritis, is another challenge.
All phagocytes, and especially macrophages, exist in degrees of readiness.
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