This may account for its reduced phosphorylation as compared to mouse NBD1 (see Figure 1A).
Upon closer scrutiny, 5 distinct rat sequences were found to have homology within the probe set of mouse Cyp2c54 (see Additional file 3).
This phenotype was particularly remarkable, because a similar pattern of responses at positive potentials was previously reported for wild-type mouse TRPA1 (see the Discussion) [ 18, 28].
Avian TLR4 ECD showed a stronger structural resemblance to human TLR4 than mouse TLR4 (see Additional file 2: Figure S4a), which suggests that avian TLR4 may exhibit similar binding features to human TLR4.
These results agree with our previous experiments showing increased ChAT expression in the spinal cord of VAChTdel mice [12]; see also Fig. 2 and 3).
Similarly, DCX immunoreactivity throughout the entire OB was 70% weaker in irradiated mice than in sham-treated mice (1.177±0.134 in sham-treated mice; 0.327±0.022 in SVZ-irradiated mice, p<0.0001; see Figure 2A and 2B).
Although control cells present unmethylated DNA, an aberrant DNA methylation pattern was observed in tumour cells of human CML (n=3) and Sca1-BCR-ABLp210 Sca1-BCR-ABLp210 Sca1-BCR-ABLp210ure 3 online).
Rab5A was unchanged in splenocytes at 4 weeks of age, but it was overexpressed at 4 months of age in NZB/W F1 mice (p=0.02; see online supplementary figure S3B).
Moreover, the regulation of Adph, Pparg Mc5r, and Scd1, 2, 3, and 4 was similar in EPGN transgenic mice and K5cre-CMVcaNrf2 mice (Fig 4B,C; see Fig 3C,D).
A more detailed GSEA of the mRNA expression data shows that both drugs deregulate a set of genes, which are also deregulated in Dnmt1 KO mouse cells [20] (see supplementary Table S2).
