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The mouse orthologue of EBP1 was first identified by virtue of its regulation through the cell cycle.
Most interestingly, the mouse orthologue of CNC7 enables activation of a LacZ reporter in the neural tube as well as in the posterior diencephalon at E11.5 [30].
Recently, a SNP in the gene timp2, the mouse orthologue of which resides on mouse chromosome 11, has been associated with preterm birth in a human population [13].
Interestingly, a recent study suggested that the mouse orthologue of CNC5 has the potential to repress transcription in embryonic stem cells [32].
Eight embryos show expression of the transgene in the somites (Figure 5B, embryos 45 909 and 45 922) indicating that the region containing the mouse orthologue of CNC8 has the ability to drive gene expression in vivo.
Recently, Brca1-Iris, the mouse orthologue of human BRCA1-IRIS, was identified (Pettigrew et al, 2008).
Similar(33)
A mir30-based shRNA library was designed to target the mouse orthologues of genes residing in the commonly deleted intervals.
We next designed a short hairpin RNA (shRNA) library targeting the mouse orthologues of deleted genes using on-chip oligonucleotide synthesis and a bar-coding strategy such that shRNAs could be amplified from the mixtures in pools of a discrete size.
The mouse orthologues of the 14 human genes used as a profile of human cartilage were also used as a profile for mouse cartilage.
By repeating the same analysis for the mouse orthologues of the human genes that had been tested above, we found 785 MGLCs in mouse.
First, we asked whether mouse transcripts orthologous to genes with increased expression in human psoriasis were disproportionately elevated in psoriasiform phenotypes, and conversely, whether mouse orthologues of psoriasis-decreased genes were disproportionately decreased in psoriasiform phenotypes.
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