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The first therapeutic mAbs were of mouse origin (indicated by the suffix -omab in INN nomenclature; see Fig. 1 for more explanation on antibody nomenclature), and frequently caused infusion reactions that could be as severe as anaphylactic responses [ 1].
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("Single origin" indicates the use of a specific kind of cocoa bean with a pedigree).
A patient with anaphylaxis and cardiac arrest was reported in the trial, most likely through IgE antibodies specific to the CAR, which used mouse-origin scFv, indicating that the potential immunogenicity of CARs derived from murine antibodies can be a safety issue, especially when CAR T cells are administered using an intermittent dosing schedule (Maus et al., 2013).
This is in contrast to OCT3/4 positive cells that did not co-localize with NUMA but instead revealed an organized staining pattern along the basement membrane indicating endogenous cell of mouse origin.
Multiple origins indicate this serotype was introduced in several episodes.
These tumors were of human origin, as indicated by histochemistry (labeling with mouse anti-human mitochondria antibody (Millipore/Biotest) applied after blocking ("mouse-on-mouse"; Vector Labs/Zotal)).
Characterization of a SCA 1 transgenic mouse model also indicated changes in the autophagic flux by vacuolar formation with autophagic origin and significant altered LC3-II/-I ratio [ 204].
Such a limit fragment is common to most tissues of origin as indicated from ENOX2 fragments produced by different tissues of transgenic mice transfected with human ENOX2 cDNA [ 17].
Many in vivo studies carried out on rat and mice models indicated inhibitory effects of fumaric acid on carcinogenesis of different origins.
The tissue of origin is indicated by different colors.
Male mice of indicated age were used for the study.
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