Also in fibroblasts obtained from Pink1 mouse mutants expressing mitochondrially targeted yellow fluorescent protein (YFP), no significant alterations in mitochondrial morphology were observed (Fig 3C and D).
Consistent with in vitro studies, mouse mutants expressing a defective form of FN1, in which α5β1 binding motif Arg Gly Asp is mutated, develop phenotypes comparable with those of integrin α5-null embryos (Takahashi et al., 2007).
I will discuss new data arising from the analysis of mouse mutant models expressing developmental disorders and susceptibility to cancer.
At day 16 post BMT, over 50% of WBCs in the p210 BCR/ABL1 mice were GFP-positive compared with ∼25% for vector and mutant expressing mice.
Bassoon immunoreactivity is located at the base of the ribbon [48] [50] and ribbons are distributed "free-floating" in the cytoplasm of photoreceptors in a bassoon null mouse mutant, which expresses a non-functional Bassoon protein [51], [52].
Thus, having generated a mouse mutant that expressed a phosphorylation deficient version of the M3-muscarinic receptor, the question was what impact did this mutation have on muscarinic receptor-mediated physiological responses?
To determine the impact of Wrn and Safb1 proteins on the health of mice, mutant animals expressing Wrn protein lacking part of the helicase domain (referred as Wrn Δ hel/ Δ hel hereafter) were crossed to Safb1-null mice.
The mouse IFT mutants express the canonical Wnt target Axin2 and activate a transgenic canonical Wnt reporter, BAT-gal, in the normal spatial pattern and to the same quantitative level as wild type littermates.
Double PSAPP mutant mice expressing mutant presenilin 1 (PS1) and APPsw also show age-dependent Aβ deposition, but also no neuronal loss (Takeuchi et al., 2000).
Recently, various genetically engineered mice, including mice lacking KATP channels (knockout mice) and mice expressing various mutant KATP channels (transgenic mice), have been generated.
