Sentence examples for mouse motor phenotype from inspiring English sources

In summary, we demonstrate that (1) MTM mice have features of a clinical disorder of NMJ transmission, (2) these clinical changes are correlated with structural changes in the NMJ, and (3) pyridostigmine, an acetylcholinesterase inhibitor, improves aspects of the MTM mouse motor phenotype.

Although the number of these two mice with a motor phenotype is too low to conclusively link the phenotype to VAPB-P56S expression, the mice shared two interesting features, i.e. the expression of ATF3, a stress transcription factor that is expressed in motor neurons following multiple pathological conditions [ 43- 45], in a large number of motor neurons.

Only mice without obvious motor phenotype were tested in the object place recognition task.

More importantly, double labeling with anti-HA antibody showed that none of the ATF3 expressing motor neurons in the mice with a motor phenotype showed VAPB inclusions.

Transgenic animals that overexpress human mutant SOD1 (SOD1 mice) develop a motor phenotype that closely mimics human disease and therefore constitute an effective model to assess the therapeutic potential of SOD1 silencing strategies.

Similar experimental passaging studies using CNS extracts from diseased mice into younger health αS transgenic mice to initiate earlier motor phenotype and αS pathology were also recently shown using αS transgenic mice with expression driven by the Thy-1 promoter [ 165].

In addition to the motor phenotype mice also presented with hyperphagia/increased body weight.

In fact, Adcy5 null mice express a dysfunctional motor phenotype consistent with a disruption in striatal dopamine signaling [ 17].

Progress is hindered in part by the lack of an adequate animal model for UCMD, as knockout mice have a mild motor phenotype.

Although loss of DAT in mice produces a dramatic motor phenotype (Giros et al. 1996), and exogenous DA can paralyze worms (Schafer and Kenyon 1995; Sawin et al. 2000; Chase et al. 2004), deletion of a large portion of the C. elegans DAT-1 gene fails to induce an overt motor phenotype on solid substrate.

No differences in input resistance or capacitance in MSNs of R6/2 mice were seen prior to the onset of the overt motor phenotype, while MSNs from behaviourally phenotypic mice showed increased input resistance and decreased capacitance.