For the TPH2KO and DKO, there were no differences between the KO or DKO and WT littermate control mice in motor coordination, acoustic startle response and sensorimotor gating, tonic inflammatory pain sensitivity, and learning and memory as assessed in inverted screen, pre-pulse inhibition, formalin paw, and trace fear conditioning assays, respectively (Table 4).
Here we present the effects of vaccine treatments in APP/PS1 mice on motor coordination, a neglected aspect of the AD experimental behavior but justified on the basis of the deficient postural control reported in patients with Alzheimer's disease [ 53], sometimes even during early stages [ 54].
To test if BK channel inactivation was related to the ataxia observed in BK−/− mice, we tested motor coordination in WT mice by the classical runway test before and after microinjection of paxilline into the vermis.
A purkinje cell-specific conditional Mof knock out mouse displayed impaired motor coordination, ataxia, a backward-walking phenotype, and a reduced life span and some of these phenotypes were very similar to the cerebellar dysfunction observed in Ataxia-telangiectasia (AT) patients [ 53].
In an evaluation of the underlying causes of decreased exploratory activity in patDp/+ mice, motor tests showed that patDp/+ mice possess normal motor coordination.
We found that exercise improved gait function in both control and HD mice and selectively improved performance in the R6/1 mice on a motor coordination aspect of the balance beam task.
Neuromuscular examination and rotarod experiments revealed that patDp/+ mice possess normal motor coordination (Table S1).
For comparison between class1 or class2 scFv effect on mice balance for motor coordination test the Wilcoxon test was used.
Thy1-haSN(A53T) mice display severe motor coordination deficits and develop subsequently neuropathology in several brain areas and degeneration of the neuromuscular junctions.
Consistent with these histological changes, Sun1 −/− and Sun1 −/−Sun2 +/− mice exhibited defective motor coordination.
