The oncogenic capacity of SYT-SSX2 was also demonstrated in a transgenic mouse model whereby SYT-SSX2, expressed in Myf5 lineage myoblasts, generated synovial sarcoma-like tumors with 100% penetrance [24].
Interestingly, several groups have observed the differential propensity of murine moncyte subsets to undergo apoptosis in a transgenic mouse model, whereby Gr1− monocytes fail to persist.
The colon-26 mouse model, whereby the murine colon-26 cells are injected subcutaneously into the flank of mice, is commonly used to study the effects of several antitumor agents, including dietary agents 47– 51.
An example of this process was definitively shown in a mouse model, whereby alterations in TGF- β signalling in stromal fibroblasts produced forestomach neoplasms and PIN (Bhowmick et al, 2004).
The role of MEF2C in postnatal muscle maintenance has been highlighted in a skeletal muscle specific Mef2c knockout mouse model, whereby sarcomeres appeared to be disorganized and fragmented [ 20].
On the basis of these findings, we propose a strategy for the HIS-CNS mouse model whereby mixed cultures of human fetal astrocytes and microglia will be transduced with lentiviral vectors that express green fluorescent protein before transplantation into the mouse brain.
Over the past 10 years, Dr. Tuohy and his team have therefore conducted research studies using three different mice models, whereby none of the mice injected with the vaccine developed any tumors at the end of the testing period.
PrP expression is central to prion susceptibility and incubation time as demonstrated in mouse models and in-vitro, whereby PrP expression is necessary for prion replication and overexpression of PrP in transgenic mice results in a decrease in incubation time (13, 23– 23).
To establish a more widely accessible method for the generation of HIS mouse models, a technique was established whereby a recipient immunodeficient mouse was simply injected with a suspension of either human fetal hematopoietic progenitor cells isolated from umbilical cord blood (CD34+ cells) or adult human peripheral blood mononuclear cells (PBMCs).
We have generated a new mouse model of tauopathy whereby pan-neuronal overexpression of the most abundant WT adult brain isoform of human tau results in the early signs of tauopathy.
