On the basis of comparisons with the Kn-9H model, it is now apparent that the neurological symptoms induced by CBE treatment are quite similar to those observed in the Kn-9H mouse model, validating the use of CBE as a means to model nGD in mice.
Recent reports indicate that inactivation of the p53 gene is detected in the stroma of human cancers, and mouse models have validated the tumor-promoting effects of deleting p53 in fibroblasts that convert them from NF to CAF. 36 We noticed that over a 160-fold increase of the miR-155 level showed a slight decrease of TP53INP1.
The treatment study using a mouse osteotomy model validated the micelles' therapeutic efficacy in promoting bone fracture healing as demonstrated by micro-CT and histological analyses.
Altogether, these results corroborate our observations in mouse models and validate the strong correlation between the loss of miR-203 and the development of skin cancer at multiple stages of tumorigenesis.
Our results also illustrate the value of mouse models in validating new drug targets in vivo and indicate that acquired chemoresistance may later influence bortezomib treatment in lung cancer.
The Searle studies predated GLP standards but their methodology was comparable; transgenic mouse models are not validated, but are accepted as supporting data.
In the current study, comparatively, we screened the MHC class II-presenting epitopes of the F protein through HLA-transgenic mouse models and eventually validated the specific CD4+ T cell responses in HCV chronically infected patients.
In the current study, we screened the MHC class II-presenting epitopes of the F protein through HLA-transgenic mouse models and eventually validated the specific CD4+ T cell responses in HCV chronically infected patients.
Moreover, in the study of nude mice model, we validated that knockdown of miR-20b expression level could suppress the tumorigenesis of breast cancer cells in vivo.
Although animal models give us insight into a potentially important role for regulatory molecules such as adenosine, it is difficult to directly translate the results from our study into the clinical care of neonates, and findings in mouse models need to be validated with further studies including higher-level animals and investigations with human samples.
