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An alternative method for generating mouse models uses the CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins) gene-editing system (see Box 2) to mutate tumour suppressor genes directly in vivo, thereby obviating the need for embryonic stem cell targeting (Sanchez-Rivera et al., 2014; Xue et al., 2014).
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Another study followed up letrozole treatment and chemotherapy on MC7-L1 and MC4-L2 tumor-bearing modelsmodels using FDG PET [11].
Here we review studies involving genetically engineered mouse models used to investigate the physiological function of individual ASIC subtypes: ASIC1 (and ASIC1a), ASIC2, ASIC3 and ASIC4.
The relationships of HO-1 expression to total CH, CH precursors and total oxysterols were determined for both mouse models using linear regression analysis.
In February, a study published in PNAS reported that the mouse "models" used extensively to study human inflammatory diseases (in sepsis, burns and trauma) have been totally misleading.
We generated type 1 diabetic mouse models using streptozotocin injections.
All mouse models used in the study were bred on a C57B6/J background.
All mouse models used in the study were on a 129sv/J × C57BL6/J mixed background.
The two mouse models used provide important confirmation for the role of RNF5 in ER stress-associated muscle degeneration phenotype.
The newly developed 15N bacteria diet provides researchers a novel tool to discover disease-relevant protein expression differences in mouse models using quantitative mass spectrometry.
CRISPR has been used to establish different cancer mouse models using a variety of techniques.
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