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Like Li, he employs mouse models to expand understanding of our own bodies.
So why is the cancer research community continuing to be dominated by the dysfunctional tradition of employing mouse models to test hypotheses for development of new drugs?
Sukhai's doctoral research involves using transgenic mouse models to study the pathogenesis of acute promyelocytic leukemia.
Selling personalized mouse models to cancer patients, a firm draws thanks and reproach.
We used in vitro cell migration and colonization assays and in vivo mouse models to characterize screening hits.
Further studies may be needed to establish specific mouse models to better evaluate the potential neuroprotective role of ursolic acid against oxaliplatin-induced neurotoxicity.
Moreover, experimental metastasis studies were conducted using B16F10 melanoma mouse models to examine the effect of micellar formulations in the prevention of metastasis.
In order to translate pre-clinical studies in cellular and mouse models to humans, differences and similarities of carboxylesterases between mice and human need to be elucidated.
In the Tylenol example, the researchers were able to use mouse models to find candidate genes and conclude that response to inflammation determines toxicity response.
"One should be very careful about transferring results from mouse models to humans," adds Markus Ege, an epidemiologist at the University of Munich in Germany.
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Alternatively, for agnostically discovered genes from GWAS, there is less concordance with mouse models to-date.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com