Sentence examples for mouse models though from inspiring English sources

Knockout experiments show a survival disadvantage in long term infection in mouse models, though the effect is tissue specific.

Several genes in our mouse models (though not Shank3) are likely to be expressed in trigeminal nucleus, which transmits sensory information to the pons and mf pathway, as well as the red nucleus and facial nucleus, which ultimately drive the production of the eyeblink.

Last fall, Bergö's group reported that ingestion of extra antioxidants drove the metastasis of melanoma in a mouse model, though they didn't have any effect on the primary tumor.

In contrast to earlier reports [13], we show that aging is not associated with proteasome impairment in our mouse model, though it is possible we may observe UPS dysfunction in mice aged beyond 18 months [13].

However, further research using in vitro slices would need to confirm any changes in the GABAergic synaptic transmission in this mouse model, though one has to keep in mind that the spontaneous activity of neurons in vitro differs greatly from activity observed in vivo.

Hence the usual approach to studying APP in neurons has been based on overexpression of the protein, either acutely in culture conditions or chronically in transgenic mouse models, even though the exogenous protein may not always traffic correctly when expressed at high levels.

Page 3: "Even though mouse models of disease are not limited to targeted gene mutation or inactivation, it has made an undisputable impact on biology and medicine".

Though mouse models have contributed greatly to our current knowledge base and treatment strategies, recapitulating the stochastic nature of human tumorigenesis in a model organism is not completely possible.

Even though mouse models of disease are not limited to targeted gene mutation or inactivation, the results of studies of the strains produced by gene targeting technology have made an undisputable impact on biology and medicine.

Though mouse models with plaque rupture are not well established, in humans, 'vulnerable' plaques that cause heart attacks often have a thin or absent fibrous cap, which is thought to make them rupture-prone.

As Boido et al. reported, significantly reduced lesion volume and improved hindlimb sensorimotor functions were observed after mouse MSCs were transplanted into the lesion cavity of compression SCI mouse model, even though the engrafted MSCs were observed to be neuronally undifferentiated and astroglial and microglial activation was not altered [ 65].