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As an anatomical reference for neuroscience research using mouse models, this paper presents DTI based atlases of ex vivo C57BL/6 mouse brains at several developmental stages.
In both mouse models this is associated with a decreased heart weight, likely secondary to a decreased after-load, while heart rate is unchanged.
In mouse models, this has been investigated in the context of invariant natural killer T (iNKT) cells and IgE.
In transgenic mouse models this cytoprotection is brought about both through improvement in muscle function and decreased apoptosis [ 32- 34].
In both Tg Dyrk1a and Dyrk1a+/− mouse models, this defect leads to an altered number of projection neurons in the most internal layer of the neocortex.
The disease onset is much later than many other tg SOD1-ALS mouse models, this is appropriate for evaluating any potential modifying effect of SOD1 loss of function.
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The last project he worked on at the Institute was a study with assistant Margaret Holmes of autoimmune disease in the New Zealand black mouse model; this mouse has a high incidence of spontaneous autoimmune hemolytic anemia.
47 In the Foxn1 nu mouse model, this neutrophil response must remain intact to prevent tumor relapse.
As FKBP51 levels were elevated in the PAE mouse model, this indicates that regulatory control is altered in these animals.
In a sepsis-induced AKI mouse model, this particular inhibitor significantly decreased the initial peritubular capillary dysfunction, as well as the subsequent tubular injury [ 59].
Much of what we know about pancreatic cancer has come from mouse models of this disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com