Sentence examples for mouse models support from inspiring English sources
Familial clustering and mouse models support the presence of monogenic causes.
Our results using preclinical mouse models support the NF-κB pathway as a potential therapeutic target for a defined subset of lung adenocarcinoma.Using small-molecule compounds that inhibit NF-κB activity, we provide evidence that NF-κB inhibition has therapeutic efficacy in the treatment of lung cancer.
The data from FHM mouse models support the view of migraine as a disorder of brain excitability characterized by dysregulation of the excitatory-inhibitory E/I balance, and point to episodic disruption of the E/I balance and neuronal hyperactivity due to excessive recurrent glutammatergic transmission as the basis for vulnerability to CSD ignition in FHM.
Studies in mouse models support Dax1 as having both pro-testis [34], [35] and anti-testis functions [33].
Evaluation of the features of RTT suggests that the basis of this disease could be an alteration of neuronal plasticity and studies of RTT mouse models support this suggestion.
These consistent findings in two different mouse models support the critical role of NADPH oxidase in down-regulating inflammation as opposed to an individual phox protein functioning independently of NADPH oxidase or an artifact introduced during generation of one of the knockout colonies.
In this review, we will discuss the molecular evidence and mouse models supporting specific 5q candidates as tumor suppressors of (del)5 or 5q– MDS and their roles in growth control.
Emerging evidence from human patients and mouse models supports that allelic heterogeneity contributes to phenotypic variability.
In later years, various knock-out mouse models supported the hypothesis that cytokines are integral in the disease process.
However, there is very strong genetic evidence from mouse models supporting endogenous FGF15׳s ability to elicit similar metabolic effects 37, 38.
Our analyses of GRP75/Mortalin and Calreticulin levels in skeletal muscle from SMA mouse models (supported by preliminary investigations of human patient tissue) suggested that these two proteins may represent robust protein biomarkers for SMA.
