Sentence examples for mouse models similar from inspiring English sources
In line, distinct engraftment phenotypes of individual patient ALL samples transplanted into xenograft mouse models similar to the NOD/SCID/huALL model used in our study were observed and associated with poor initial patient response.
Analysis of a larger series of tumors would be needed to determine the relevance of this observation and may lead to the formulation of a modified WHO classification for mouse models, similar to the one formulated for peripheral nerve sheath tumors in mouse models (25).
This is particularly appealing when one considers that quinacrine (QC) and chlorpromazine (CPZ), two compounds already in clinic for a long time for other applications and recently tested in human for compassionate treatment of CJD, were totally inefficient in human as well as in a mouse model similar to the one we used [25], [26], even in combination.
In a collagen-induced arthritis mouse model, similar results were found and, importantly, BiP was able to both prevent and treat arthritis [ 56].
The association between miR-200b expression and pathophysiological features of NASH was demonstrated in livers of a mouse model similar to human NASH.
To study the effect that the expression of BCRP has on the efficacy of STX140 in vivo, we used a dual xenograft tumour mouse model similar to that established in our laboratory to study the effect of P-glycoprotein expression on STX140 efficacy (Newman et al, 2008).
Knockout mouse models revealed similar essential functions for desmosomes in skin cell cell adhesion.
60 Thus, mouse models with similar genetic mutations have been generated to provide phenotypic and mechanistic insights.
Instead, for each group of human breast cancer, multiple mouse models showed similar predicted pathway activation profiles.
Our PLPCre; Nf1floxed and CNP-HRas mouse models were similar to GFAP-Cre; Nf1fl/− mice, with optic-nerve enlargement and myelin disorganization (Kim et al., 2010).
The different Tet2 knockout mouse models exhibit similar phenotypes but also present subtle differences that might be due to the loss of different regions of the gene.
