Sentence examples for mouse models results from inspiring English sources

There is significant evidence demonstrating that increasing levels of the dystrophin-related protein, utrophin, in mouse models results in sarcolemmal bound utrophin and prevents the muscular dystrophy pathology.

PDZK1 has been shown to be involved in the hepatic expression of SR-BI/CLA-1 [58] and PDZK1 knockdown in mouse models results in a decrease of SR-BI expression in the liver and intestine [59].

As discussed above, in vivo transplantation of undifferentiated hESCs in mouse models results in teratoma formation.

We have shown that targeted deletion of this gene in experimental mouse models results in the loss of neuronal cell populations in the central nervous system (CNS).

Systemic administration of miR-26a with adeno-associated virus in mouse models results in decreased cancer cell proliferation and suppressed tumor progression [ 23].

Surgical ablation of endodermal regions corresponding to prechordal plate in both chick and mouse models results in defective forebrain patterning, cardiac fusion, and foregut morphogenesis, supporting a role for prechordal plate in development of anterior-ventral tissues also affected in Foxa2 loxP/loxP; Isl1-Cre mutants (Camus et al., 2000; Withington et al., 2001).

While gene variants of FGFR2 may influence the risk of hypospadias in humans [26], conditional inactivation of FGFR2 in mouse models resulted in blockade of the XY-specific gonad growth and disruption of testis differentiation, leading to a male-to-female sex reversal phenotype.

Different mouse models resulting in either a null allele or Mecp2 truncating mutations recapitulate RTT-like phenotypes (14– 14).

The take-home lesson here is that the majority of these mouse models result in tumors that resemble human breast adenocarcinomas pathologically.

Dramatic effects of PGRN deficiency have been shown in vivo in collagen-induced arthritis and collagen Ab-induced arthritis mouse models, resulting in fulminant courses of disease [ 14].

Immunotherapy targeting amyloid deposition in both mouse models resulted in decreased alternative inflammatory markers and, in the case of passive immunization, a transient increase in pro-inflammatory markers.