Sentence examples for mouse models relevant from inspiring English sources
Genetic mouse models relevant to schizophrenia complement, and have to a large extent supplanted, pharmacological and lesion-based rat models.
9, 10 However, a causative role for oxidative stress in axonal degeneration in mouse models relevant to human disease has, to the best of our knowledge, not yet been formally proven.
Although it would be interesting to develop methods to reduce basal metabolic rate in humans based on the response seen a mouse model, relevant qualitative as well as semiquantitative information on the benefits of therapeutic strategies could still be obtained using small mammals.
In fact, this pattern is also displayed before Tau pathology onset in a well established mouse model relevant to Tau aggregation in Alzheimer's disease.
To analyse relevance of the findings described above, 2D analysis of Tau was performed in a recent characterized transgenic mouse model relevant to Tau pathology in Alzheimer's disease [1].
Nonetheless, the results are in accordance with data obtained from mechanistic studies in a mouse model relevant for human lipoprotein metabolism (6– 8).
Furthermore, our study focuses on a mouse model relevant to early onset AD, which accounts for <5% of all cases human of AD.
In humans, autophagic buildup is present in many muscle cells in late-onset patients (both juvenile and adults), thus making the observations in the mouse model relevant to the human study.
Altogether, these facts stress the need to investigate systematically whether the data generated in mouse models is relevant in a clinical setting.
Nonetheless, since these compensatory changes occur in both simulated and true reproductive aging, the manipulation of gonadectomy in mouse models remains relevant to the human condition.
Moreover, the use of a tissue specific cancer model, like the p53R270H/+WAPCre mouse model, is relevant to assess the intrinsic pro-carcinogenic potential of mitogenic and non-mitogenic biologicals such as insulin analogues.
