The evaluation should focus on protection from the acute stage of infection in both mouse models, reflecting the need to protect humans from rapidly fatal disease.
None of these two mouse models reflects human AD pathology because none showed significant neurofibrillary tangle pathology and both overexpressed a transgenic construct made to produce large amounts of Aβ [ 16, 20].
Additionally, pharmacokinetics, biodistribution, and clearance route are studied after intravenous injection in a mouse model, reflecting their overall safety.
In addition, pharmacokinetics, biodistribution, as well as clearance of nanoparticles were studied after intravenous injection in a mouse model, reflecting their overall safety.
On the other hand, "not everything seen in a mouse model reflects what happens in humans," cautions Betty Diamond, chief of rheumatology at Columbia University.
We first evaluated the antifibrotic properties of the monoclonal anti-IL-6R antibody, MR16-1, in the bleomycin-induced dermal fibrosis mouse model, reflecting early and inflammatory stages of SSc.
As an example, a recent study established that reduced cerebellar size in an NF1 mouse model reflects postnatal functions of the Ras-MAPK pathway and its negative regulation by NF1.
In order to develop and standardize a mouse model reflecting the human situation of metabolic syndrome with diet-induced obesity, adipose tissue inflammation promoting insulin resistance and atherosclerosis we investigated the effect of a common high-fat diet and a sucrose-enriched high-fat diet in LDLR-/ mice.
Absence of these factors in mice implies that gut microbiota in mouse models cannot reflect a 'real-life' gut microbiota.
Summary: We present initial data from systematic and longitudinal analyses of hepatocarcinogenesis using mouse models that reflect the human disease.
