However, the lack of appropriate mouse models recapitulating the CID G/AI is a stumbling block to characterize the pathophysiology of this phenotype23.
Genetically engineered mouse models recapitulate many features of human cancer and have been instrumental in assigning biological meaning to specific cancer-associated alterations.
Several mouse models recapitulating features of AD pathology have been used to investigate whether the process of neurogenesis is altered in the disease and whether it contributes to cognitive impairments (see refs in [26]).
Genetically engineered mouse models recapitulating specific pathway abnormalities such as double transgenic c-myc/TGFα mice might be more successful at predicting clinical response.
Several mouse models recapitulate the cardinal features of human oligodendrogliomas (ODGs) (Holland, 2001a, 2001b, 2001c; Betsholtz, 2004; Shih et al, 2004; Salpietro and Holland, 2005).
However, relatively little is known about whether RTT mouse models recapitulate the unique features of progression, regression and stabilization that define the human disease.
Although, Mecp2 mutant mouse models recapitulate key characteristics associated with RTT patients including an initial phase of apparently normal development followed by severe neurodevelopmental dysfunction, there is evidence that mouse models are an underrepresentation of the human condition (19– 219.
Although induction of prostaglandin E2 pathway promotes gastric tumors in mice in cooperation with deregulated Wnt or BMP signalings, it has remained unresolved whether the gastric tumor mouse models recapitulate either of human gastric cancer type.
Given the BMI1-high/ TP53-low molecular signature associated with Group 4 MB, and the resultant phenotype observed in mouse models recapitulating this genotype, we characterized the transcriptional network associated with BMI1 expression in this molecular subgroup.
Having defined distinctive gene expression patterns among the PCT subtypes as well as between PCTs and BCLs, we next sought to examine how well our mouse models recapitulate human phenotypes as measured by relative similarities of gene expression patterns.
