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Pathology plays a pivotal role in bespoke, hypothesis-driven investigations of mouse models, providing important insight into the morphological consequences and mechanisms of gene function (Schofield et al., 2011).
In our current study, Cuc IIa suppressed cancer cell expansion in cell culture as well as in tumour bearing mouse models, providing a new drug candidate for anti-cancer therapy.
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Our study, together with evidences from C. elegans and mouse models, provides an important cue to WS therapy.
Collectively, these transgenic mouse models provide interesting new insights regarding pathophysiological functions of GSH in the liver.
Genetically engineered BCC mouse models provide one important tool for the study of the biology of human BCCs and for evaluating therapeutic interventions, as these mice produce multiple genetically defined tumors within a relatively short period of time.
Mouse models provide important information regarding pharmacokinetics and in vivo efficacy of novel compounds [15] [17], [54] [57].
However, since Trpc6 is ubiquitously expressed and the reported transient overexpressors do not show any selectivity our mouse models provide novel tools to study the contribution of podocyte dysfunction in the pathogenesis of FSGS.
Mouse models provide an opportunity to study such mechanisms.
Utilizing mouse models provides excellent immunological and experimental tools to study oral immune responses.
Mutant mouse models provide an opportunity to better understand the molecular pathology that drives these diseases.
Finally, mouse models provide evidences that this region is associated with schizophrenia.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com