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Our study, together with evidences from C. elegans and mouse models, provides an important cue to WS therapy.
Utilizing mouse models provides excellent immunological and experimental tools to study oral immune responses.
The recent availability of several peroxisome-deficient mouse models provides an excellent opportunity to directly test the GABA/DBI model of Zellweger pathogenesis.
The recent generation of AGR2 inducible knockout and overexpression mouse models provides opportunities to study the mechanisms of AGR2 in breast cancer and other adenocarcinomas [ 20].
Overall, the variety of mouse models provides a useful toolbox for the analysis of genetic and environmental factors that affect immune-cell activation and self-reactivity.
Gait analysis, which has been performed in both rat and mouse models, provides indirect but not direct measurement and quantification of inflammation [ 22, 23].
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Collectively, these transgenic mouse models provide interesting new insights regarding pathophysiological functions of GSH in the liver.
Genetically engineered BCC mouse models provide one important tool for the study of the biology of human BCCs and for evaluating therapeutic interventions, as these mice produce multiple genetically defined tumors within a relatively short period of time.
Mouse models provide important information regarding pharmacokinetics and in vivo efficacy of novel compounds [15] [17], [54] [57].
However, since Trpc6 is ubiquitously expressed and the reported transient overexpressors do not show any selectivity our mouse models provide novel tools to study the contribution of podocyte dysfunction in the pathogenesis of FSGS.
Mouse models provide an opportunity to study such mechanisms.
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