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The previously generated HCV transgenic (HCV-Tg) mouse models produced inconsistent results concerning the role of HCV proteins in HCC development.
These Swiss nude mouse models produced a 12.5% stable take rate (25/200) and ten models with lung metastases.
Similar inclusions were reported in some of the DYT1 mouse models produced by expression of transgenic human torsinA but this has not been a consistent finding [ 28, 29].
As genetic links to these disorders are established and transgenic mouse models produced in efforts to understand and treat them, there is a surprising lack of information on electrocardiograms (ECGs) and ECG abnormalities in neonate mice.
At the single cell level we found that neurons in both DS mouse models produced fewer action potentials in a given measured time for repetitive spiking at all current steps in which action potentials appeared (Fig. 4).
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Most mouse models produce only ERα-negative tumors.
The authors suggest that APPSL/PS1Ki mice, compared to the other mouse models, produce exceeding amounts of N-truncated A βx-42, also found in AD brains [ 135].
Meanwhile, a mouse model produced by intraperitoneal EV71-infection (106 TCID50), was used to investigate the protective effects of Reduning injection.
Another possible complicating factor is the fact that our mouse model produced severe OA by 56 days post-injury.
43 In the lung adenocarcinoma mouse model produced by Kras mutation and Wnt signaling activation, enhanced proliferation and EMT of lung cancer cells, as well as downregulation of Sox2 and upregulation of Sox9 and Gata6, were observed, in comparison with the lung adenocarcinoma mouse model produced by Kras mutation only.
Furthermore, this study is the first to demonstrate that loss of Cav-1 in a transgenic mouse model produces neuropathology similar to that exhibited with AD, i.e., Aβ production, elevated astrogliosis, reduced cerebrovasculature and neuronal loss in the hippocampus.
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