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The studies published so far were conducted in different mouse models, on different tissues and at various developmental stages.
JAF assisted TAT, AZ and EMS on the NPD recordings in the two different CF mouse models on behalf of the UAB CF Center.
We hereby propose that serum- and feeder-free B6 ES cells stimulated with LIF plus GSK3 inhibitor are valuable for generating mouse models on B6 background.
Gross motor dysfunction and shortened lifespan are common features of diverse RTT mouse models on different genetic backgrounds and broadly recapitulate the clinical presentation in individuals with RTT (Table 2; supplementary material Table S3).
In summary, our study demonstrates the importance of testing mouse models on different genetic backgrounds and comparing males and females in order to find the most appropriate disease model for therapeutic studies.
Our study demonstrates the importance of testing mouse models on different genetic backgrounds and comparing males and females in order to find the most appropriate disease model for therapeutic studies.
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Wap-p53R172H mice were obtained from the Mouse Models of Human Cancer Consortium on an FVB background.
Research on mouse models of motor neurone disease (MND) have demonstrated the important of a growth factor called VEGF.
In a mouse model on rejection of an allogeneic subcutaneous tumor as created by Hammond-McKribben et al. [22], another mTOR inhibitor, the rapamycin derivate SDZ RAD, was used to prevent rejection of allogeneic tumors.
BMS309403, a specific A-FABP inhibitor, was found to have remarkable impact on the inhibition of atherosclerosis in the apo E-/ mouse model on a western diet [9].
APPPS1-21 mice are a recently generated transgenic mouse model on a C57BL/6J genetic background that co-expresses the KM670/671NL mutated human amyloid precursor protein and the L166P mutated human presenilin 1 (APPPS1-21 mice) and model aspects of cerebral amyloidosis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com