It is important to note that, although transplantation of rod photoreceptors is showing improved efficacy in mouse models, obtaining cone photoreceptor integration and survival remains elusive.
The germfree mouse model obtained by setting the bounds on all reactions in iAH991 to 0 mmol gDw−1.hr−1.
Interestingly, the characterization of a liver-specific conditional mouse model (obtained through deletion of the frataxin gene using the albumin-promoter-driven Cre recombinase) showed that frataxin deficiency caused liver tumorigenesis, suggesting that frataxin is a tumor suppressor protein.
The APPswe/PSEN1dE9 (APP/PS1) transgenic mouse model, obtained from the Jackson Laboratory (Stock number 004462; Bar Harbor, ME, USA), harbours two human transgenes: the amyloid beta precursor protein gene (APP) containing the Swedish mutation; and the presenilin-1 gene (PS1) containing a deletion of exon 9 [ 23].
The in vivo giardicidal effect of 4 was evaluated in a CD-1 mouse model obtaining a median effective dose of 1.709 μg/kg (3.53 nmol/kg), a 321-fold and 1015-fold increffectivenesstiveness after intragastric administration over metronidazole and nitazoxanide, respectively.
Furthermore, Dinulescu et al. forced expression of oncogenic KRAS or conditional PTEN deletion in ovarian surface epithelium of a mouse model obtaining preneoplastic ovarian lesions with an endometrial glandular morphology, while the combination of both gave rise to invasive and widely metastatic endometrioid ovarian cancer [ 72].
The first PC transgenic mice model obtained was the PC2 null mouse (Furuta et al. 1997).
She discovered a new approach for MR imaging of tumor associated macrophages (TAM) with iron oxide nanoparticles in mouse models and obtained an IND to carry out the first TAM imaging trial in pediatric patients.
GAA-based mouse models were obtained using either a knock-in approach based on homologous recombination or a human genomic yeast artificial chromosome (YAC) transgenic approach.
Previous studies on tauopathy mouse models have obtained divergent results with regard to dendritic spines: While in most models, the spine density was found to be reduced [ 8- 10], in others an increased [ 12] or unchanged spine density [ 13] was observed.
