Interaction of Rspo2 with key members of this pathway have been recently described (33), and interestingly, mouse models involving disruption of other members of this pathway (Dlx5, Dlx6, Hand2 and Edn1) also score in the top 50 matches.
Several transgenic mouse models have been generated using the members of the VEGF family.
Moreover, there are several mouse models of impairing mutations in several members of the Wnt family that present cleft palate as one of the phenotypes [ 34].
Some of the earliest evidence that NFκB also posses anti-inflammatory effects was derived from studying mouse models with targeted deletions of NFκB family members (Table 2).
The thymopoietic phenotypes of Cdc42−/− mice are reminiscent of and complementary to the previous observations in mouse models deficient in Rac1, Rac2 or RhoH, other members of Rho family GTPases.
The summer student project would entail working with more senior lab members in a variety of ongoing projects involving mouse models, biochemistry, or bioinformatic analysis, or computational modeling.
We thank the members of Molecular Oncology Lab for helpful discussions; Mouse Models of Human Cancers Consortium MMHCCC) Repository, a NCI-funded resource, for providing Rb1tm2Brn mice.
We have examined the expression of BPIFB1 (LPLUNC1), the prototypic two-domain containing family member, in lungs from CF patients and in mouse models of CF lung disease.
Triple knockout mouse models proved the tumor suppressor properties of FOXOs, as mice simultaneously lacking the principal members of the mammalian FOXO subfamily, FOXO1, FOXO3a and FOXO4, are prone to develop hemangiomas and lymphoproliferative diseases [26].
All members of the RUNX family, most notably Runx2, are known to promote tumorigenecity in mouse models [24], [25].
