Multiple mouse models involving genes important in surfactant production and regulation relevant to lung disease observed in human newborns have been created.
In contrast, knockout mouse models involve complete ablation of gene function, abolishing any activity of the corresponding protein.
Among transcripts decreased in human psoriasis, there was even stronger similarity among mouse models, involving a broad range of biological processes for which expression patterns were correspondent between psoriasiform phenotypes and human (e.g., response to insulin stimulus, development, transcription; see Figure 7).
28 However, experimental data in various knockout mouse models involving different angiotensin-converting enzyme components fail to support this theory.
To understand the role of ɛ-SG in the cardiac muscle, we generated two mouse models involving ɛ-SG: (i) the Sgce-null mouse, and (ii) the Sgca-; Sgce-null mouse by crossing Sgca-null (23) and Sgce-null mice.
Transcription factors, including NF-κB, are implicated in experience-based synaptic regulation, and mouse models involving altered NF-κB activity have revealed the importance of the various forms of this transcription factor in learning and memory (reviewed in [ 26]).
Interaction of Rspo2 with key members of this pathway have been recently described (33), and interestingly, mouse models involving disruption of other members of this pathway (Dlx5, Dlx6, Hand2 and Edn1) also score in the top 50 matches.
Mouse models involving Neb deficiency, dominant ACTA1 mutations and dominant TPM3 mutations recapitulate features of the human disease and have been instrumental for advancing knowledge about the pathogenesis of NM.
Burgstaller et al. (2014) recently addressed this issue of a limited number of mtDNA pairings by producing novel mouse models involving mixtures of standard and several new, unexplored, wild-derived haplotypes which capture a range of genetic diversity.
Importantly, the A53T α-Syn+/+ mouse model involves an age-dependent neurodegeneration.
