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Outstandingly, a multiple-shRNA expression system targeting different regions of FMDV genome showed broad antiviral effects against seven serotypes of FMDV [ 19]; better still, transgenic mouse models integrating siRNAs targeting 3D and 2B1 genes of FMDV have been established [ 20].
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PBPK models integrating both disposition (i.v).v
Similarly, the RCAS/tv-a system is a mouse model that integrates orthotopic cell transplantation into a transgenic mouse.
What's needed is a transition to a new model, integrating social, environmental and economic factors.
A model integrating these different levels of information is proposed.
Using a transgenic mouse model harboring chromosomally integrated lacZ mutational target genes, we previously demonstrated that mutations accumulate with age much more rapidly in the small intestine than in the brain.
As it is able to analyze global metabolic changes in biofluids it is an appropriate tool for comparing GHR mutant mouse models and allows us to integrate metabolite data with our previous microarray study [19].
Systematically profiling stem cells using pathprints to integrate data from mouse models, human primary tissue, and clinical studies will resolve the contributions of these stem cell pathways to developing and aberrant systems and reveal pathways of clinical relevance.
Studies in mouse models have uncovered that adeno-associated virus integrates with high-frequency on chromosome 12 near Meg3 gene locus [ 42].
To directly assess the levels of different types of spontaneous mutations in organs and tissues during aging, we have used a mouse model harboring a chromosomally integrated cluster of lacZ-containing plasmids that can be recovered and analyzed in Escherichia coli.
They also want to expand the phenotypic classifications to allow for a greater sample size and integrate other data such as those from mouse models of neural tube defects.
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