Sentence examples for mouse models in from inspiring English sources

Ongoing challenges include modeling complex multigenic disorders, and validating genetically engineered mouse models in drug development and preclinical testing.

One alternative is to use genetically engineered mouse models in which specific mutations selective to the myocyte can be produced.

Using mouse models in which HIF-1α and HIF-2α are overexpressed in intestinal epithelial cells demonstrate a distinct function for these transcription factors in IBD.

This chapter contains methods that are particularly useful for the basic characterization of transgenic mouse models in which the expression of keratin genes has been manipulated.

The most commonly used genetic mouse models in this preclinical field and the principal findings that have emerged from these studies are summarized.

To address this issue, we developed mouse models in which immature thymocytes are the only positively selecting antigen-presenting cells in the thymus.

Fortunately, the advent of rapid, low-cost in vivo somatic modeling techniques (e.g. CRISPR), enhances the utility and impact of mouse models in biomedical research.

The feasibility of these approaches will need to be tested in mouse models in vivo.

Thus, our TLX1 mouse model joins other T-ALL mouse models in which activating NOTCH mutations occur spontaneously.

Previous results have shown an increased kinetics of wound closure in diabetic mouse models in response to sNAG treatment.

This is in line with established transgenic mouse models in which both parenchymal and vascular amyloidosis could be found [27].