Sentence examples for mouse models illustrated from inspiring English sources

Experiments using either xenograft or genetic mouse models illustrated that deficiency in Skp2, TRAF6 or TRAF4 results in suppression of cancer development in vivo, pointing to the critical role of distinct E3 ubiquitin ligases in Akt-mediated biological functions and cancer progression.

Transgenic mouse models illustrate its importance: when interleukin (IL 13 is overexpressed, mice show induction of MMPs and develop emphysema [ 27]; by contrast, TNFα knockout mice are relatively protected from emphysema after smoke exposure [ 28].

Most of the probesets (54) could not be associated with a single mouse model, illustrating at least in part how relatively uncharacterized the cartilage genome is.

The development of mAIP in the Tgfbr2 fspKO mouse model illustrates the role of TGFβ in maintaining myeloid DC immune tolerance.

Moreover, PB1-F2-knockout influenza virus induced less cell death than the wild-type virus in the mouse model, illustrating the role that PB1-F2 may play in promoting the apoptosis.

The Tgfbr2fspKO mouse model illustrates that a signaling pathway known to suppress cell-cycle progression when activated in epithelial cells can also have an indirect inhibitory effect on epithelial proliferation when activated in adjacent stromal fibroblasts in vivo.

Finally, a prior study in a telomerase knockout mice model illustrated that short telomere length could even be the cause of hypertension, rather than its consequence [ 26].

In vivo noninvasive observations in the nude mice model illustrated that PAMAM-Es with a dose-dependent effect had been more effective on inhibiting the growth of endometriotic lesions and avoiding ESCs affected than the Lipofectamine Es.

Our adipose VEGF loss- and gain-of-function mouse models further illustrate that repetition of fasting-induced adipose-VEGF expression underlies IF-mediated metabolic benefits.

This chapter discusses the basic methodology used in the creation of mouse models and illustrates their strengths and limitations.

Here we discuss representative examples from fly and mouse models to illustrate the ongoing success of this tripartite strategy, focusing on the ways it is enhancing our understanding of visual processing and other sensory systems.