Sentence examples for mouse models identified from inspiring English sources
Previous studies using mouse models identified sphinganine variants of α-galactosylceramide as promising iNKT cell activators that stimulate cytokine responses with a strongly proinflammatory bias.
Functional evaluation of three analogous human TEX11 missense mutations in transgenic mouse models identified one mutation (V748A) as a potential infertility allele and found two mutations non-causative.
Several studies both in human and based on mouse models identified some regions of human chromosome 21 (Hsas1) as linked to cognitive deficits.
Interestingly, investigation of SS using inbred mouse models identified Gpa33 as one of a handful of genes deleted in two SS susceptibility loci (Nguyen et al., 2008).
Summary: The comparison of different nephron-specific Wt1-knockout mouse models identifies the stage of origin of human WT1-mutant Wilms' tumours.
Separating the two types of Wilms' tumours through phenotypic overlap with these two mouse models identifies clear biological differences between the tumour types.
Studies on this mouse model identified previously unknown molecular pathways that are induced by GM1 accumulation and result in neuronal apoptosis and neurodegeneration [10], [11].
Mapping of EGF induced liver cancer in a transgenic mouse model identified n = 96 (p < 0.05) significantly regulated proteins of which n = 54 were tumour-specific.
Later, a mouse model identified a putative endogenous GSC located at the apex of a cellular hierarchy that was involved in tumor maintenance and recurrence after chemotherapy.
Further studies using the MST1 deficient mouse model identified that the role of the up-regulated MST1 kinase was to promote the development of muscle atrophy, rather than functions as an adaptive mechanism to prevent rapid loss of muscle mass.
Our systems biology analysis of genome-wide expression data from salivary gland tissue of pSS patients and from a pSS mouse model identified common dysregulated biological pathways and molecular targets underlying critical molecular alterations in pSS pathogenesis.
