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Moreover, functional studies of the ALS-causing optineurin mutations and the recently established optineurin ubiquitin-binding deficient and knockout mouse models helped identify three major mechanisms likely to mediate neuroprotection: regulation of autophagy, mitigation of (chronic) inflammatory signaling, and blockade of necroptosis.
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In related studies, BDNF deficient and null mice models helped to prove that gait coordination [ 16], cerebellar development [ 17, 18], and function [ 19] are BDNF-dependent processes.
New information from the mouse model helps to describe variation in meat quantity and quality, and thus contribute to research in livestock.
New information from the mouse model helps to describe variation in meat quantity and quality and thus supports research in livestock.
Mouse models have helped a lot, he said.
Much has been learned from gene "knock out" mouse models that helped to identify major synaptic regulators.
Here we discuss the role of β-AR signaling in the normal and abnormal heart and how the use of genetically engineered mouse models has helped in our understanding of the pathophysiology of cardiac disease.
Here we discuss the role of beta-AR signaling in the normal and abnormal heart and how the use of genetically engineered mouse models has helped in our understanding of the pathophysiology of cardiac disease.
LRH provided MMTV mouse models and helped with data analysis.
Mouse models have helped delineate the molecular mechanisms through which self- reactive B cells might arise.
The use of transgenic mouse models has helped to analyze c-Myc-induced mammary tumorigenesis [ 17- 19], but little is known about the normal physiological function of c-Myc in the mammary gland.
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