Sentence examples for mouse models found from inspiring English sources
Previous work in experimental mouse models found there to be positive genetic correlations between virulence, asexual density and transmission [ 24].
However, some studies using mouse models found that metformin induced insulin resistance and hyperinsulinemia, which suggested that the anticancer effect of metformin may be mediated by reduced serum insulin levels [ 184].
To date, studies examining hippocampal-dependent spatial learning/memory in AD mouse models find no effects of gonadal hormone depletion [ 159 , 160] or estradiol replacement [ 159 , 160]in water maze tasks, despite estradiol-mediated decreases in Aβ levels or deposition [ 161- 168].
A recent study in a mouse model found Lgi1 gene expression to be most prominent within intrahippocampal circuitry (Herranz-Pérez et al., 2010).
Another study from our lab using the 5T2MM mouse model found that the degree of hypoxia in MM BM was less than that in normal BM.
A targeted approach using the TRAMP (transgenic adenocarcinoma of the mouse prostate) mouse model found a general increase in the expression of ECM-modifying proteases, such as MMPs and cysteine proteases, during tumor progression [ 42].
A study by Hebbard et al. (2010), where GFP expression was driven by the Melk promoter in a mouse model, found a high expression of Melk in mouse mammary progenitor cells, but the functional role of Melk in these cells was not determined.
On the other hand, experiments in mice models found that TLR9-deficient mice had a higher level of protection against reinfection [ 38].
A few studies have tried conformation selective monoclonal antibodies therapeutically in AD mouse models and found this to have beneficial effects [13] [15].
Furthermore, in comparing NTG with PSAPP and APP−/− transgenic mouse models, we found that LDLR protein levels were directly proportional to the amount of APP.
We have previously standardized the CAG repeat size and strain background of the R6/2 and HdhQ150 knock-in mouse models and found that they develop a comparable and widespread neuropathology.
