Sentence examples for mouse models even from inspiring English sources

The knowledge generated in mouse models, even in humanized mouse models, is not directly applicable to humans.

The co-delivery of endostatin and docetaxel by PEI-modified TPGS-b- PCL-ran-PGA) NPs significanTPGS-b- PCL-ran-PGAumor growTPGS-b- PCL-ran-PGAdels (even regress 80% esTPGS-b- PCL-ran-PGA

Hence the usual approach to studying APP in neurons has been based on overexpression of the protein, either acutely in culture conditions or chronically in transgenic mouse models, even though the exogenous protein may not always traffic correctly when expressed at high levels.

However, the mechanisms leading to spine loss may differ between mouse models even if they share similar transgenes [ 228].

In mouse models, even low-dose mercury exposure caused pancreatic islet β-cell dysfunction by inducing oxidative stress and phosphatidylinositol 3-kinase activation (7).

Moreover, with well-set-up standardized mouse house facilities throughout labs in the world, conducting experiments on mouse models, even germ-free ones, can be more easily achieved than with other models.

Data from an ovarian cancer orthotopic mouse model even demonstrated that co-targeting CAF glutamine synthetase and cancer cell glutaminase can disrupt such a metabolic crosstalk, inducing pronounced disease regression (Yang et al., 2016).

This makes the mouse model even more atractive to be used as a tool for studying immune response to BTV and vaccination strategies.

Using an elegant mouse model, Even's group demonstrated that MdmX is a better drug target than Mdm2 in lymphoma.

Haploinsufficient loss of Fbxw7 is observed in most lymphomas in the mouse model, even those arising from Fbxw7/p53 double heterozygous mice [ 17].

Significantly, SAHA and the clinically available BRAF inhibitor vemurafenib cooperatively inhibited BRAFV600E melanoma xenograft growth in a mouse model even when caspase-3 was inhibited.