Sentence examples for mouse models especially from inspiring English sources

We and others have previously seen spontaneous carcinomas in the liver in many mouse models, especially in old female mice with balb/C background [32] and also the transgenic expression of hVEGF-A165 especially in the lungs was low (mouse endogenous VEGF-A164 levels were 25 times higher than hVEGF-A165).

The generation of familial ALS mouse models, especially SOD1, has helped clarify several important aspects of the disease pathogenesis, but a precise molecular mechanism is still lacking.

p53 has been shown to contribute to the pathogenesis of metabolic disease in mouse models, especially under conditions of nutrient excess.

These results indicated that LAM-resistant HBV mouse models, especially triple mutations, were established successfully and can be used to evaluate the efficacy of anti-viral compounds against drug-resistant HBV infection.

The differences in the histopathology of the tumours arising in mice compared to those in women have been a major limitation of many mouse models, especially as they suggest a different target cell population for the initiating event.

Clearly, additional mouse models, especially those with conditional over expression of Trim24, and manipulation of diet, along with mechanistic studies of functional domains and intersecting pathways, are needed to determine how epigenetic variables and tissue-specificity dictate metabolic reprogramming by TRIM24.

"We want to battle the perception … that [researchers] have to do as much in humans as they would in a mouse model, especially if the finding is important for a clinical application," says Ushma Neill, executive editor of The Journal of Clinical Investigation.

These cytokines and the chemokine have been generally used in CS-induced mouse model, especially for COPD in previous studies [ 21, 68, 69].

DCC expression was reduced in human intestinal-type as expected, while the reduction of the gene was observed in the mice model, especially in K19-Wnt1/C2mE K19-Wnt1/C2mE

This application is particularly important in the in vivo study of AOM, as in vivo experiments in mouse models are especially labor intensive due to the small amount of recoverable ME mucosal tissue, making the piecewise assessment of individual genes difficult and expensive.

The predicted physicochemical property precisely state their specificity as CNS acting agent and antidepressant-like effect of the most promising compound 10 after oral administration significantly reduced immobility in mice behavior models, especially TST from 63 s.