Sentence examples for mouse models engineered from inspiring English sources

The focus of our research has been a series of mouse models engineered to carry mutations in genes known to be involved in human cancer". Professor Jacks received his bachelor's degree in biology from Harvard College, and his doctorate from the University of California, San Francisco, where he trained with Nobel Laureate Harold Varmus.

Reprogrammable mouse models engineered to conditionally express Oct-4, Klf-4, Sox-2 and c-Myc (OKSM) have been instrumental in dissecting molecular events underpinning the generation of induced pluripotent stem cells.

These features are similar to several mouse models engineered to perturb the WNT pathway (Batlle et al, 2002; Sansom et al, 2004; Madison et al, 2005; Finch et al, 2009).

The intestinal epithelia of these mice showed several similarities to mouse models engineered to perturb the WNT pathway (Batlle et al, 2002; Sansom et al, 2004; Madison et al, 2005; Finch et al, 2009).

A mouse model engineered with signature mutations would provide a powerful ally in the study of pancreatic cancer biology and may guide improved prognostic assessment and treatment for the human disease.

The protective effect of RTL therapy on the iatrogenic effect of primary tumour resection could be tested in a tri-transgenic mouse model engineered to express potent oncogenes in a doxycycline-dependent mammary-specific manner [ 32].

The homeostatic T cell regulation of tumours can be tested in a tri-transgenic mice model engineered to express potent oncogenes in a doxycycline-dependent manner.

Mouse models are engineered for biomedical studies, bacteria are engineered to produce medications such as insulin, and crops are engineered for agriculture.

At Harvard Medical School, Dr. Cantley's laboratory has been utilizing mouse models, genetically engineered with mutations in the PI3K pathway, to investigate opportunities for therapeutic intervention in diseases that result from defects in the PI3K pathway.

Furthermore, mouse models with engineered defects in the Rb-phosphorylating kinases provide evidence that moderation of Rb inactivation may be a strategy for the prevention of tumour formation.

In vivo plaque labeling was evaluated in a transgenic mouse model (Tg2576) engineered to produce excess amyloid plaques in the brain.