Sentence examples for mouse models designed from inspiring English sources

Atlases annotated with gene expression data have increased value for comparisons with mouse models designed to study genetic perturbations of developmental processes.

Transgenic mouse models designed to recapitulate genetic and pathologic aspects of cancer are useful to study early stages of disease as well as its progression.

Therapeutic efficiency can be improved by selecting for target-antigen reactive Treg, as indicated by preclinical mouse models designed to study the prevention of autoimmunity [12] [14] and graft-versus-host disease [4], [6], [7].

Altered intrinsic properties have been reported in mouse models designed to investigate psychiatric disease (Kehrer et al., 2007; Gisabella et al., 2009; Kvajo et al., 2011).

Xenotransplant mouse models designed for studying the targeting of [H]-labelled liposomes and antitumour activity support the usefulness and potency of this approach and a combination of liposomes with anti-apoptotic and chemotherapeutic payloads.

However, overexpression of wild-type PrP is toxic to mice (Chiesa et al., 2008; Watts et al., 2012; Westaway et al., 1994), making it difficult to distinguish the effects of the mutation from any confounding effects associated with overexpression in mouse models designed this way.

Genotype and sex dependent differences in longevity have important implications for designing experiments with Alzheimer's mouse models, comparing genotype and sex differences in aging mouse models, designing drug treatment regimes and the translation of mouse data to human clinical studies.

describe a mouse model designed to examine the biological effects of different levels of deregulated c-myc expression.

This study investigated the effect of acupuncture on iron-related oxidative damage in a mouse model designed as a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP -induced parkinsonisMPTP -induced

A mouse model designed to investigate the expression pattern of miR-145 revealed expression of miR-145 in multipotent cardiac progenitors and smooth muscle cells [29] and suggested that miR-145 promotes the differentiation into smooth muscle cells [29].

DOI: http://dx.doi.org/10.7554/eLife.05161.011 In this study, we report on a transgenic mouse model designed to control cAMP signaling in sperm using optogenetics.