Sentence examples for mouse models describing from inspiring English sources
To date, development of mouse models describing diabetic macrovascular disease has been limited.
This review describes the state-of-the-art for generating such models, provides an overview of the types of genetically humanized mouse models described to date and their applications in basic research, drug discovery and development and to understand clinical drug toxicity.
The novel mouse models described here will be useful tools for future studies addressing this question in more details.
Similar to the lung cancer mouse models described above, in these EGFR mutated lung cancers behave in an oncogene-addicted fashion following treatment with EGFR tyrosine kinase inhibitors [33], [63].
The data also imply that the mouse models described here would be very useful in several aspects.
Unlike the HIS mouse models described above, in the HIVE mouse model cells already infected with HIV are implanted directly into the brain.
Several studies have used some of the mouse models described in this Commentary to try to tease out the mechanistic connection between these two diseases.
The ability to spatially and temporally control gene expression in both oncomice and tumor suppressor knockout mice using this model has provided methods of overcoming some of the early limitations of mouse models described above.
To focus on early time points of muscle atrophy, we relied on three mouse models described elsewhere: CLP surgery that mimics sepsis, denervation-induced atrophy and food deprivation [ 13, 25, 26].
NAC has a long safety record in the treatment of acetaminophen poisoning in humans where it is used intravenously at high doses, resulting in serum concentrations comparable to those used in cell and mouse models described here (41).
Similarly, testing the role of the adaptive immune system or the mechanical properties of the intestinal epithelial barrier could be addressed using the cell transfer or transgenic mouse models described above.
