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So far, no mouse models deficient in Fam162a, Ccdc58, Csta, or Stfa2l1 have been described.
The spermatocytes in defective Ing2−/− seminiferous tubules underwent meiotic arrest (Fig. 2G), which was also observed in mouse models deficient for histone methyltransferases [10], [11], [12].
Recently, the function of AAMs was addressed either by depleting them or by using mouse models deficient in their signature molecules like Arg1 and Fizz1.
Increased DA levels in the absence of neurodegeneration were also reported for PD mouse models deficient only in Parkin (PARK2) [32] and in some in vitro studies of A53T-SNCA [20], [33], [34].
A common feature of a number of mouse models deficient for proteins in the Cdk4/cyclinD/E2f pathway is a defective glucose homeostasis due to an impaired maintenance of pancreatic β-cells [5] [8].
The thymopoietic phenotypes of Cdc42−/− mice are reminiscent of and complementary to the previous observations in mouse models deficient in Rac1, Rac2 or RhoH, other members of Rho family GTPases.
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A mouse model, deficient for TMEM165 in the mammary gland, exhibited decreased secretion of lactose into milk, which reduced the osmotic potential of the milk, decreasing its volume, and concentrating the protein and nutritional metals it contains.
By conditionally deleting the antiapoptotic gene cellular FLICE-like inhibitory protein (C-FLIP) in myeloid cells, we have generated a novel mouse model deficient in marginal zone and bone marrow stromal macrophages.
We chose the Rag1-/ mouse model deficient in both mature T and B lymphocytes [23].
The Müller glial cell-targeted gene transfer was tested in a mouse model deficient for Crumbs homologue 1 (CRB1) that exhibits retinal degeneration accompanied by Müller cell gliosis.
We present the first evidence from a mouse model deficient in ankyrin-B that ankyrin-B variants can be viewed as balanced variants with increased risk of sudden death and early aging offset by increased cardiac contractility.
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