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Derived aneuploid mouse models correspond to the deletion and the reciprocal tandem duplication of the corresponding target region, namely Ts1Yah for the trisomy and Ms2Yah for the monosomy of the Abcg1 U2af1 region (Fig. 1A and B).
Our MuRF1 and MuRF2 KO mouse models correspond both to constitutive null models (for details on gene targeting, see Supplementary Figure 1B D).
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Determining the specific type of hematopoietic lesion produced in a mouse model and identifying mouse models that correspond to the human subtypes of these lesions has been a continuing challenge for the scientific community.
Therefore, because the JAG2 haplotype was fixed under selection in the LL and not in the FL, and because JAG2 appears as a negative regulator of adiposity in mouse models, this selected haplotype should correspond to a "gain-of-function" mutation in JAG2.
Our results correspond well to studies in other mouse models that have implicated MMP-13 in development of arthritis.
There are now mouse models of Parkinson's.
The problem is there are no appropriate mouse models that can mimic the human situation.
"We have observed that they increase the susceptibility to respiratory infections in the mouse models.
(Much of the earlier work has also been corroborated by other labs, also using mouse models).
Like Li, he employs mouse models to expand understanding of our own bodies.
They are not prepared to accept that mouse models are basically valueless for most of cancer therapeutics.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com