Sentence examples for mouse models containing from inspiring English sources
Interestingly, the hallmark phenotype of all long-lived mouse models containing mutations that induce GH/IGF-1 deficiency or resistance, is their enhanced insulin sensitivity [ 6].
Genetically engineered mouse models containing a single lesion detected in humans with myeloid leukemia may develop leukemia only after long latency or not at all, suggesting that additional cooperating mutations are required.
We have previously reported the generation of human FXN yeast artificial chromosome (YAC) transgenic FRDA mouse models containing 90 190 GAA repeats, but the presence of multiple GAA repeats within these mice is considered suboptimal.
The T2/Onc transposon used in previous mouse models contains elements to terminate transcription and promote over-expression after the transposon inserts in or near a gene [10], [11].
Using EM and AFM we have demonstrated that the brains of both the R6/2 and HdhQ150 knock-in mouse models contain a diverse and comparable range of Htt aggregate structures.
These results suggest that one or more of the 23 genes that are in three copies in Ts65Dn but not in Ts1Cje are responsible for the MPD, whereas the trisomic region shared between the two mouse models contains a gene(s) that contributes to the macrocytic anaemia.
Therefore, a mouse model containing activated glial cells with prominent cytoplasmic branching processes and hypertrophied nuclei, namely the soman-intoxicated mouse, was chosen.
We have generated a transgenic mouse model containing in its genome a loxP-STOP inactivated hVEGF-A165 expression cassette, which can be activated by Cre gene transfer in any tissue at any point during life [25].
We describe a mouse model containing a modified Mbd5 gene that severely decreases Mbd5 expression.
Gazit and colleagues [ 68] generated a transgenic mouse model containing the luciferase promoter under control of an osteoblast-specific osteocalcin promoter fragment.
Only two recent mouse models have been generated that comprise genes from the telomeric region: the Tc1 transchromosomic mouse model containing an almost complete (∼82%) human chromosome 21 [38] and a model trisomic for all human chromosome 21 syntenic regions [56].
