Sentence examples for mouse models caused from inspiring English sources
The ablation of Paneth cells in several mouse models caused recoverable loss of Lgr5+ stem cells (Sato et al., 2011).
Previous research showed that 1 enhanced the cellular and humoral immunity in mice, and increased the phagocytic activity of macrophages in immune-depression mouse models caused by massive doses of hydrocortisone and hydroxycarbamide [ 12].
Loss of Wnt1 or β-catenin in mouse models caused severe abnormalities in midbrain and cerebellar development by preventing specification of the midbrain hindbrain boundary (McMahon and Bradley, 1990; Thomas and Capecchi, 1990; Schuller and Rowitch, 2007).
Exercise in mouse models causes neurogenesis in the dentate gyrus.
Global constitutive activation of ACVR1 in mouse models causes embryonic lethality; however, transgenic mice containing a Cre-inducible constitutively active allele (ALK2 Q207D) have been developed (Fukuda et al., 2006).
For example, posttranscriptional control of tumor necrosis factor-α (TNF-α) expression has been extensively reported, and increased expression of TNF-α, caused by impaired control of its mRNA degradation, leads to just over twofold increase in mRNA half-life which, in mouse models, causes severe autoimmune disease (7, 8, 32).
Prenatal cocaine exposure in a mouse model caused a decrease in both GABA neuron migration from the basal to the dorsal forebrain and radial neuron migration in the dorsal forebrain.
Heterozygous deletion of Becn1 in an AD mouse model caused increased neurodegeneration, decreased autophagy, and disruption of the lysosomal system [41].
The results of this study suggest that JNK may play a different role in mammary carcinogenesis because neither JNK1-deficiency nor JNK2-deficiency in the Trp53 BALB/c mouse model caused a reduction in the incidence of mammary carcinoma.
Furthermore, SRF overexpression in a transgenic mouse model caused hypertrophy and cardiomyopathy [ 67].
Similarly, breast cancer TS/A-derived exosomes injected into a mouse model caused an increase of MDSCs within both the primary tumor and the spleen [ 132].
