Sentence examples for mouse models carriers from inspiring English sources
However, markers of tissue damage characteristic of inflammation, apoptosis and ROS (reactive oxygen species) generation have been found in tissues of human and transgenic mouse models carriers of mutant TTR variants, well before amyloid deposits can be detected [ 8– 10].
We delineate the effect of RNAi in GBM cell lines, describe their effectiveness in glioma mouse models, and compare the proposed drug carriers for the effective transport of RNAi molecules through the BBB to reach the tumor in the brain.
The finding that no difference in EPSC frequency was observed at the youngest ages in any line of HD mouse models suggests that presymptomatic HD gene carriers are likely to have more normal excitatory inputs to MSNs.
Of note, a polymeric formulation of CPT, CRLX101, has been clinically evaluated, and it was demonstrated that the improved pharmacokinetics and tumor penetration of nanoparticle (NP -based carriers observed iNP -basedodels were maintained in patients, highlighting the therapeuticarriersial that new fobservedons hold for thin parental mouseule.
Furthermore, a reduced number of GEMs is observed in ALS spinal cord motor neurons [ 188], fibroblasts derived from FUS or TDP-43 mutation carriers [ 214] and ALS mouse models [ 65, 101, 173].
Using mouse models, it has been recently demonstrated that THTR1 along with THTR2 are involved in carrier-mediated thiamine uptake by pancreatic acinar cells (Subramanian et al., 2012).
Whilst chronic typhoid carriers exhibit impaired humoral and cellular immunity [ 5], rapid priming of CD4+ T cells in mouse models of Salmonella infection was reported to elicit effective Th1 responses [ 21].
There are now mouse models of Parkinson's.
The problem is there are no appropriate mouse models that can mimic the human situation.
Like Li, he employs mouse models to expand understanding of our own bodies.
"We have observed that they increase the susceptibility to respiratory infections in the mouse models.
