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THZ1 also inhibits other cancers in mouse models, but the compound hasn't yet been tested for safety or efficacy in people.
The drug DMXAA (5,6-dimethylxanthenone-4-acetic acid) showed therapeutic promise against solid tumors in mouse models but subsequently failed in human clinical trials.
Rajendran hopes Matters can also help level the playing field for researchers in poorer areas, who may lack resources such as antibodies and mouse models, "but can still make good observations".
ARM-relevant choroidal neovascularization and cell loss have been productively studied in mouse models but bona fide drusen have been a more elusive target [83], [84].
Toll-like receptors (TLRs) play a critical role in initiating the innate immune response to many pathogens in mouse models, but little is known about their role in human infections.
The microarray-based analytical approach we have implemented does not replace conventional validation criteria for psoriasis mouse models, but extends these criteria by providing a quantitative "yardstick" that can be used to clearly judge progress towards more realistic mouse phenotypes.
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Finally, we have demonstrated that our findings are valid not only in mouse model but also in human TNBC.
We show that these properties collectively reduce the risk of organ infections and vertical transmission in a mouse model but remain sufficiently immunogenic to prevent wild-type ZIKV infection.
This approach has worked successfully in a genetically engineered mouse model but failed in humans, paradoxically increasing mortality in the treatment arm.
Nevertheless, treatment with these blood-brain barrier impermeable drugs delays, yet does not prevent, late-onset paralysis; a common manifestation in this immunodeficient mouse model but not in humans.
The B. melitensis B115 rough strain has demonstrated its efficacy against B. melitensis virulent strains in the mouse model, but there is a lack of information regarding its potential use in small ruminants for brucellosis control.
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