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We also recapitulate other mouse models available for the study of premature aging.
There are many mouse models available to study the mechanisms of obesity [39].
Moreover, in contrast to several well defined and characterized experimental podocyte disease models in rats such as the passive Heymann nephritis, puromycin nephrosis, the remnant kidney model and others [5], the number of mouse models available to study podocyte diseases are limited in number, and are also substantially less well defined.
Our results show the GarsC201R/+ mouse is an important addition to the range of mouse models available for studying neurodegenerative disease, both in directly modeling the human GARS mutation phenotypes and for teasing out the molecular interactions leading to pathogenesis in other neurodegenerative disorders.
There are an additional 19 mouse models available directly from CMGCC investigators.
Currently, there are numerous mouse models available partially reflecting the human syndrome.
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However, it is really rare to "re-open" the investigation if there is a mouse model available since it is considered risky to regenerate a different mouse model with a hope of a different result.
Indeed, the first MDS mouse model available supports this concept: Slape and colleagues recently showed that BCL-2 overexpression in NHD13 mice corrects macrocytic anemia and delays leukemic transformation.
At Present, there are almost no spontaneous or induced or genetically engineered mouse model available to study both hematogenous and regional lymph node dissemination with involvement of liver, spleen, heart and lungs even though it is the most frequent mode of dissemination for human breast cancer.
This review will summarize the most commonly used of the genetic mouse models currently available for PD research.
Several immunodeficient mouse models are available for selection based on the experimental design and the type of tumorigenicity assay.
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