Sentence examples for mouse models associated from inspiring English sources

In addition, no naturally occurring mouse models associated with loss of other DGC components are available.

Moving forward, the mouse models associated with Fragile X-Associated Disorders (Fragile X Premutation and Full Mutation) will be an essential tool for informing human disease research as well as for preclinical interventional studies.

Mouse lplunc1 RNA has been shown to be elevated in multiple mouse models associated with increased goblet cells (Barnes et al. 2008) and we are presently evaluating if all airway goblet cells human diseased human lung tissues stain for the protein.

Deletion of Ddit3, the gene encoding CHOP, has also been reported to reduce cell death in multiple tissues in several disease mouse models associated with ER stress including a neurotoxin-induced Parkinson disease model, the demyelinating Charcot Marie Tooth 1B mouse model, and a model of diabetes (36– 36).

Other mouse models associating a susceptibility to epilepsy with neuronal lamination defects, such as p35, Lis1 and reeler mutant mice, show severe hippocampal pyramidal cell defects affecting both the CA1 and CA3 regions [45] [47].

In line with this, transfusion of platelets can induce transfusion-associated immunomodulation in a mouse model, associated with the expression of platelets MHC class I antigens [14].

This study was designed to address the effects of a moderate consumption of beer on serum and liver lipid parameters and on the development of aortic lesions in a mouse model associated with a human atherogenic lipoprotein profile.

The Krt14-Cre DKO mice that exhibited weight loss during the water loss assay also displayed skin phenotypes observed in other mouse KO models associated with skin barrier defects: thin red shinny skin with areas of dry flaky skin (Koch et al., 2000; Gladden et al., 2010).

Because very similar changes in gene expression are observed in Esrp1/Esrp2 DKO epidermis as those in other mouse KO models associated with barrier defects, we believe these changes in EDC genes and Keratins are mostly an indirect effect of the Esrp KO, in contrast to the direct regulation of Grhl1 by AS-NMD.

Reduced PPARγ in mouse models is associated with lipodystrophy and reduced life span (Argmann et al., 2009).

These results indicate that oncogenic Ras activation in two genetically defined mouse models is associated with NOX4 induction, consistent with our observations in cultured cells.