This research allies basic research, preclinical studies using mouse models and translational studies using patient samples.
Ramirez, N. E. et al. The α2β1 integrin is a metastasis suppressor in mouse models and human cancer.
Chen, J., McKay, R. M. & Parada, L. F. Malignant glioma: lessons from genomics, mouse models, and stem cells.
MSH2 knockout in mouse models and its knockdown in human cell-based assays nearly eliminates expansions10,40,41.
We approach this using a combination of molecular and cellular analyses, mutant mouse models, and genetic screens in zebrafish.
We are addressing this question using mutant mouse models and the resulting E2F/pocket protein deficient cells.
We are extending these studies to additional mouse models and testing effects of ataxin 2 lowering in human cell models.
Both classes increase permeability of tumor vasculature in mouse models, and DMXAA in particular can cause massive tumor necrosis.
In this review, we discuss OSCC mouse models and their use in cancer research worldwide.
These obstacles are being overcome by genetically engineered mouse models and newly developed high-resolution ultrasound.
Systemic, enzyme-mediated depletion of L-arg has been investigated in mouse models and human trials.
