Sentence examples for mouse models achieved from inspiring English sources

In addition, inhibition of TGF-β activity and/or expression in mouse models, achieved using neutralizing antibodies or targeted homologous gene disruption or expression of dominant negative forms of receptors, results in accelerated lesion development (in ApoE−/− mice) and an elevated inflammatory response [6,8,9].

22 Similarly in our mouse model achieving temperatures between 36.5 and 37.5 °C using dry-cold CO2 for insufflation was difficult requiring continuous intervention with a heat lamp.

Presently available mouse models can achieve a high degree of predictive validity for positive outcomes of experimental therapies, but they have been less successful in identifying potential adverse outcomes that can occur in human trials.

Additionally, no PWS mouse model has achieved a disease phenotype identical to that seen in human PWS patients, which suggests that there are species-specific differences that prevent mice from exhibiting the full human PWS phenotype [ 44].

Robust phenotypic correction of diseases in mouse models has been achieved paving the way toward the first clinical trials.

Thus, we identified a subset of possible target genes for Alzheimer's disease that were interrogated in two different Alzheimer's mouse models and human samples achieving a high correlation between the groups.

Plaque regression or stabilisation, a key clinical goal, has been achieved in mouse models, most notably in the Reversa mouse – a mouse in which hypercholesterolaemia (due to knock out of the LDL receptor) can be conditionally reversed [110].

Exciting advances in translating discoveries achieved from mouse models and molecular strategies to the clinic have led to a flurry of new therapeutics specifically designed to target eosinophil-associated diseases.

These studies have progressed and inhibition of Gas6 or the Axl receptor has been achieved in mouse models.

Our results clearly demonstrate that this simple method of using ICG as a depot injection to label cells in vivo can be achieved in mouse models.

In a typical fish facility containing 2000 10 000 adult pairs of fish, the capacity to test hundreds of candidate genes serially or in parallel dwarfs what can be achieved in mouse models.