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In fact, other than Ptc, Tp53 is the most frequently targeted gene in MB mouse modelling, in spite of the fact that Tp53 mutation (both homozygous and hemizygous deletion) alone very rarely induces MB formation.
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The mouse model, in particular, does not represent the human condition.
All vaccine candidates were evaluated in a mouse model in prime only or prime-boost regimens.
CSCs were first found in a leukemic cell transplanted mouse model in the 1960s (Bruce and Van Der Gaag, 1963).
One study is conducted on mouse model in which multiple surgical wounds treated with different skin substitutes.
The mouse model, in particular, exhibits early severity-dependent metabolic down-regulation soon after the initiation of sepsis.
Results demonstrating the applicability in the mdx mouse model in vitro and in vivo will be presented.
Therefore, we generated an AADC deficient mouse model, in which compensatory regulation allowed the mice to survive to adulthood.
Ongoing challenges include modeling complex multigenic disorders, and validating genetically engineered mouse models in drug development and preclinical testing.
One alternative is to use genetically engineered mouse models in which specific mutations selective to the myocyte can be produced.
We set up an ad hoc mouse model in which TEMs, and not Tie2-expressing endothelial cells, are targeted.
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