Sentence examples for mouse modelling from inspiring English sources

Ideally, a faithful recapitulation of human disease in genotype and phenotype is an essential element of mouse modelling.

A series of highly recurrent mutations in genes such as TP53, KRAS, SMAD4, BRAF, MLL3, ARID1A, PBRM1 and BAP1, which are known to be involved in cell cycle control, cell signalling pathways and chromatin dynamics, have led to investigations of their roles, through molecular to mouse modelling studies, in cholangiocarcinogenesis.

The most informative mouse modelling studies are discussed first.

Mouse modelling of Nf1-haploinsufficiency clearly shows a permissive tumorigenic environment in NF1, although the actual mechanism is unclear [ 4].

The different mouse modelling technologies described above have been applied to studies of MB biology, genetics, and preclinical research.

In fact, other than Ptc, Tp53 is the most frequently targeted gene in MB mouse modelling, in spite of the fact that Tp53 mutation (both homozygous and hemizygous deletion) alone very rarely induces MB formation.

There are now mouse models of Parkinson's.

"Blocking tumor necrosis factor in a mouse model improves asthma," Dr. Remick said.

The problem is there are no appropriate mouse models that can mimic the human situation.

"We had the virus, the mouse model, and two vaccines to test".

Like Li, he employs mouse models to expand understanding of our own bodies.