Sentence examples for mouse model whose from inspiring English sources
Accordingly, we resorted to the construction of a reporter transgenic mouse model whose marker gene (membrane-targeted Venus; mVenus) was placed under the control of the Ccr1 promoter.
Using such a TGFa-transgene-expressing TG mouse model whose gastric mucosa showed a strong resistance to ethanol injury, we found that the integrative mechanisms of TGFa involve at least three categories of cytoprotective regulators: NO synthases in relation with gastric blood flow, COX-2, and apoptosis-associated regulators such as Bcl-2 and Bax.
The lab is applying single cell methods to brains and other tissues to characterize mouse models whose genetic or nutritional manipulations impart phenotypes relevant to human health and disease; we also apply them to human disease specimens.
In general, the generation of novel mouse models, whose MC deficiency is independent of a c- Kit-mutation, offer new insights in MC biology, but their relevance for different systems must be individually examined.
One of the emphases of this study is that we did not use severe combined immunodeficiency mice-transplantation model, but used MLL AFF1 Tg mice model whose immune systems are basically normal.
For this purpose, we used the MMTV-PyMT murine model whose oncogenesis is induced by expression of the polyoma virus middle T oncoprotein under control of the Mouse Mammary Tumour Virus (MMTV) promoter (PMID: 1312220).
When comparing the germfree with the microbe associated mouse model, we identified 266 nutrients, whose associated exchange fluxes changed in at least one diet (Fig. S5 ; Table S4 ).
The previously reported transposon-mediated mutational screen of a pancreatic ductal preneoplasia mouse model identified a series of genes whose targeted inactivation cooperated with KRASG12D in the development and progression of PDA [ 9].
Using NeuCode, we characterize an inducible knockout mouse model of Bap1, a tumor suppressor and deubiquitinase whose in vivo roles outside of cancer are not well established.
A mouse model shows that menin is an essential protein whose absence results in embryonic lethality, whereby heterozygous mice develop endocrine tumors, consistent with its role as a classic tumor suppressor for the endocrine lineage.
However, it was possible to make use of mouse model to do drug research related to 15-delta prostaglandin J2, whose target was a nuclear receptor.
